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modafinil will minimize the extent or effect of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.itraconazole will increase the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Istradefylline forty mg/day amplified peak ranges and AUC of CYP3A4 substrate